Manchester United are looking to climb back into the top-four on Tuesday evening, whilst Fulham could be relegated.
United face a tricky looking test at Wolves – a fixture they lost last month in the FA Cup quarter-finals.
The evening’s other game see Watford host Fulham, and a home win will see The Cottagers drop back to the Championship, joining Huddersfield who were relegated at the weekend.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Watford 19:45 Fulham
TEAM NEWS: Tom Cleverley is the only player missing for Watford – but they could rest players ahead of their FA Cup semi-final this weekend.
Alfie Mawson remains sidelined for Fulham who are also set to be without Aleksandar Mitrovic, but Tim Ream and Jean Michael Seri could.
KEY FACT: Fulham have picked up two points from a possible 48 away from home in the league this season
MATCH ODDS: Watford 4/6 Draw 16/5 Fulham 17/4
bet365 Pick: Over 2.5 goals & Both Teams To Score @Evens
ANDY SAYS: Comfortable Watford win and Fulham are down…3-0
GRAEME SAYS: Fulham are going down with a defeat here…2-0
Football Index – One to follow: Ryan Sessegnon – Will he stick around at Fulham if they go down?
Wolverhampton Wanderers 19:45 Manchester United
TEAM NEWS: Wolves, who have a fully fit squad to choose from, have Ryan Bennett available for selection but they could rest a number of players ahead of their FA Cup semi-final this weekend.
Alexis Sanchez, Antonio Valencia, Eric Bailly and Matteo Darmian all remain out for Man United, but Anthony Martial, Romelu Lukaku and Victor Lindelof are all set to be available.
KEY FACT: United are looking to avoid consecutive away defeats against Wolves in all competitions for the first time since August 1980
MATCH ODDS: Wolves 3/1 Draw 13/5 Man Utd Evens
bet365 Pick: Man United to win @Evens
ANDY SAYS: I think this plays out as a draw…1-1
GRAEME SAYS: This depends what team Wolves put out, so I think United win this…1-3
Football Index – One to follow: Diogo Jota – A huge talent, who is attracting big interest