Manchester United could close close the gap on neighbours and Premier League leaders Manchester City with victory on Tuesday evening.
United travel to Watford looking to avoid a third successive away defeat but they face a tough task at Vicarage Road. The Hornets know that victory would lift them into the top-six.
Tottenham travel to Leicester, knowing that three points at the King Power Stadium would take them into third place whilst the Foxes could move into the top-half of the table with the win.
Brighton entertain Crystal Palace in the M23 derby as the two big rivals meet for the first time since 2013. Bottom-of-the-table Palace would lift themselves to third from bottom with victory, whilst Brighton are looking to maintain their excellent form – which already sees them in ninth place.
West Brom, still under caretaker Gary Megson, entertain Newcastle – both of whom are looking for their first wins on over a month.
See below for a run-down on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Brighton & Hove Albion 19:45 Crystal Palace
Amex Stadium
TEAM NEWS: Beram Kayal is fit again for after a broken leg but Steve Sidwell is out. Chung-yong Lee and Connor Wickham are both out for Palace.
KEY FACT: Crystal Palace have lost only two of their past 12 matches against Brighton
MATCH ODDS: Brighton 17/10 Draw 21/10 Palace 2/1
bet365 Pick: Palace @2/1
ANDY SAYS: Always a big game this one, and will be close – think it will be a draw…1-1
GRAEME SAYS: Tough one, I believe that this could go Palace’s way…2-3
SILKY SAYS: A close game, not sure I can go either way so a draw…1-1
FOOTBALLIndex – One to follow: Ruben Loftus-Cheek is in fine form and at £1.55 looks good value
Leicester City 19:45 Tottenham Hotspur
King Power Stadium
TEAM NEWS: Harry Winks is a major doubt, but Erik Lamela is available for the first time in over a year. Matty James and Robert Huth remain sidelined for Leicester.
KEY FACT: Harry Kane has netted more career goals versus Leicester than he has against any other team
MATCH ODDS: Leicester 4/1 Draw 29/10 Spurs 3/4
bet365 Pick: Spurs @3/4
ANDY SAYS: Have to go with Spurs here, but will be close…1-2
GRAEME SAYS: I think Tottenham should have the edge in this one…1-2
SILKY SAYS: Tottenham just have the edge here for me, but Leicester will run them close…1-2
FOOTBALLIndex – One to follow: Riyad Mahrez available at £1.45 looks a good buy
Watford 20:00 Manchester United
Vicarage Road
Live On BT Sport
TEAM NEWS: Eric Bailly and Phil Jones could both be available, but captain Michael Carrick remains sidelined. Tory Deeney is available again for Watford, but Miguel Britos, Craig Cathcart, Younes Kaboul, Nathaniel Chalobah and Isaac Success are all out.
KEY FACT: Man Utd are aiming to avoid losing three successive Premier League away matches for the first time since 1996
MATCH ODDS: Watford 17/4 Draw 29/10 Man Utd 8/11
bet365 Pick: Under 2.5 Goals @Evens
ANDY SAYS: Tough call this one but I think Watford are getting something from United…1-1
GRAEME SAYS: Could be a good game this one, but yeah a draw for me here…2-2
SILKY SAYS: Two good teams and there will be goals, but a draw…2-2
FOOTBALLIndex – One to follow: Richarlison is on the up – looks a good buy at just over £2
West Bromwich Albion 20:00 Newcastle United
The Hawthorns
TEAM NEWS: Chris Brunt, Nacer Chadli and James Morrison. Isaac Hayden is back after his ban and Mikel Merino could return.
KEY FACT: West Brom have won two of their last three home league matches against Newcastle
MATCH ODDS: West Brom 11/8 Draw 21/10 Newcastle 5/2
bet365 Pick: Salomon Rondon first goal @6/1
ANDY SAYS: I can see West Brom coming out on top here but won’t be pretty…1-0
GRAEME SAYS: I don’t see many goals here, indeed could see this being goalless…0-0
SILKY SAYS: Has to be a draw for me, I think they will cancel each other out…1-1
FOOTBALLIndex – One to follow: Just under £1, Salomon Rondon is only just outside the top 200