Liverpool have the chance to extend their lead at the top of the Premier League table to seven points on Wednesday.
The Reds will have been boosted by the shock loss of Manchester City on Tuesday, and they will look to take full advantage of that as they host Leicester City.
Tottenham and Chelsea look to maintain their grip on the top-four. Spurs host Watford at Wembley, whilst Chelsea travel to Bournemouth.
The final game is a huge one at the bottom as 16th plays 17th with Southampton hosting Crystal Palace – both are just three points above the drop-zone.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
AFC Bournemouth 19:45 Chelsea
TEAM NEWS: Chris Mepham is set to make his Bournemouth debut following his move from Brentford, but fellow new boy Dominic Solanke is still not fit. Top-scorer Callum Wilson is a doubt with a knee problem.
Chelsea are ready to give a Premier League debut to their new Argentine loan signing Gonzalo Higuain.
KEY FACT: Bournemouth have lost all three Premier League home fixtures versus Chelsea.
MATCH ODDS: Bournemouth 17/4 Draw 16/5 Chelsea 4/6
bet365 Pick: Both Teams To Score @3/4
ANDY SAYS: Tough game for Chelsea and I think that Bournemouth have enough to claim a draw…1-1
GRAEME SAYS: Chelsea need a win here and I think they can get it…0-2
Football Index – One to follow: Callum Hudson-Odoi – a huge talent and one who should be in the mix
Southampton 19:45 Crystal Palace
TEAM NEWS: Matt Targett is a doubt with a knee injury, but Charlie Austin, Kayne Ramsey and Mario Lemina are set to miss out.
Wayne Hennessey and Vicente Guaita are fit again and will battle it out to start in goal with Julian Speroni. Bakary Sako is involved after re-joining the club on-loan.
KEY FACT: Crystal Palace are aiming to avoid a third consecutive league defeat
MATCH ODDS: Southampton 7/5 Draw 12/5 Palace 11/5
bet365 Pick: Both Teams To Score @3/4
ANDY SAYS: I am going with my former team here, I think they can take the win…1-2
GRAEME SAYS: Southampton have not been too bad, I can see them taking the three points…2-0
Football Index – One to follow: Wilfried Zaha – could easily be some real value on Palace’s leading man
Liverpool 20:00 Leicester City
TEAM NEWS: Liverpool look likely to be without Dutch pair Virgil van Dijk and Georginio Wijnaldum, but Fabinho and Dejan Lovren are available. James Milner is still suspended.
Daniel Amartey remains sidelined for Leicester, but they will have Harry Maguire available.
KEY FACT: Leicester have lost six of their last seven Premier League away games at Anfield
MATCH ODDS: Liverpool 1/4 Draw 11/2 Leicester 14/1
bet365 Pick: Liverpool to win & Both Teams To Score @7/4
ANDY SAYS: Comfortable home win on the way…3-0
GRAEME SAYS: Leicester are decent but you have to go with Liverpool…2-0
Football Index – One to follow: Jamie Vardy – still a top class striker and one to be considered
Tottenham Hotspur 20:00 Watford
TEAM NEWS: Spurs welcome back forward Son Heung-min following his Asian Cup duty with South Korea. Moussa Sissoko is also back but Ben Davies joins Harry Kane and Dele Alli on the sidelines.
Watford are without Kiko Femenia, Sebasitan Prodl and Abdoulaye Doucoure.
KEY FACT: Watford are looking for a first ever double over Tottenham
MATCH ODDS: Spurs 4/6 Draw 3/1 Watford 19/4
bet365 Pick: Over 2.5 goals & Both Teams To Score @11/10
ANDY SAYS: I think Spurs’ form has been really poor and I can see Watford taking a shock win…1-2
GRAEME SAYS: With Son back, I think he will tip the balance in Spurs’ favour, but it will be close…2-1
Football Index – One to follow: Son Heung-min – quality player well worth investing in