The top-six are all in action on Wednesday evening.
Liverpool are back at the top of the table and lead by one point, and they will look to stay there as they host Watford.
Manchester City host West Ham United, knowing victory would take them back top – should Liverpool slip-up.
The game of the evening takes place at Stamford Bridge as third place Tottenham travel to rivals Chelsea. If results went their way, Spurs could move to within two points of top-spot, whilst victory for sixth-placed Chelsea could see them into fourth.
Arsenal moved into fourth place over the weekend and they will stay there if they beat Bournemouth at The Emirates.
Should Arsenal fail to win then Manchester United could move back above them as they take on Crystal Palace at Selhurst Park.
The final game of the evening is an archetypal ‘six-pointer’ as third bottom Southampton host second bottom Fulham at St Mary’s.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Arsenal 19:45 AFC Bournemouth
TEAM NEWS: Arsenal are waiting on Alex Iwobi, Stephan Lichtsteiner and Ainsley Maitland-Niles but they hope all three will be fit.
Bournemouth midfielder Jefferson Lerma is suspended, whilst Steve Cook, Callum Wilson, David Brooks and Junior Stanislas remain sidelined.
KEY FACT: Bournemouth’s only win in eight competitive fixtures against Arsenal came at the Vitality Stadium last season
MATCH ODDS: Arsenal 4/9 Draw 4/1 Bournemouth 13/2
bet365 Pick: Arsenal win & Under 3.5 goals @6/4
ANDY SAYS: Arsenal are fresh off a good win, and they will take the three points…3-1
GRAEME SAYS: Don’t see an issue with Arsenal getting the win here, too strong at home…2-0
Football Index – One to follow: Mesut Ozil – Does he still have value? Perhaps…
Southampton 19:45 Fulham
TEAM NEWS: Michael Obafemi has suffered a re-occurrence of his hamstring injury, and he joins Danny Ings and Mario Lemina on the sidelines.
Fulham have a fully fit squad to choose from with Alfie Mawson fit again.
KEY FACT: Southampton are unbeaten in 19 home league matches versus Fulham, dating back to 1935
MATCH ODDS: Southampton 10/11 Draw 27/10 Fulham 10/3
bet365 Pick: Fulham To Score over 2.5 goals @9/4
ANDY SAYS: Southampton need the win and for me they get it without too many issues…2-0
GRAEME SAYS: Close game and think Fulham might be able to claim a point…1-1
Football Index – One to follow: Aleksandar Mitrovic – The Serb has been great for Fulham, well worthy of investment
Chelsea 20:00 Tottenham Hotspur
TEAM NEWS: Chelsea could drop goalkeeper Kepa, following his antics in the League Cup final. Gary Cahill and Danny Drinkwater are sidelined, but Davide Zappacosta could be available.
Eric Dier and Dele Alli remain sidelined but they are the only absentees for Tottenham.
KEY FACT: The last time Chelsea lost both league games in a season to Tottenham was in 1971
MATCH ODDS: Chelsea 13/10 Draw 5/2 Spurs 9/4
bet365 Pick: Draw @5/2
ANDY SAYS: Close call, I can’t separate them, has to be a draw…1-1
GRAEME SAYS: This really could go either way, but I can see Spurs bouncing back to form with a win…1-2
Football Index – One to follow: Harry Kane – Still value left in the England captain
Crystal Palace 20:00 Manchester United
TEAM NEWS: Mamadou Sakho has been ruled out with a knee injury, joining Connor Wickham and Pape Souare on the sidelines. They are hoping Martin Kelly and Aaron Wan-Bissaka will make the game.
United are without a host of first-teamers including Ander Herrera, Anthony Martial, Jesse Lingard, Juan Mata, Phil Jones, Nemanja Matic, Matteo Darmian and Antonio Valencia. Marcos Rojo and Marcus Rashford should be involved.
KEY FACT: Crystal Palace have yet to beat Manchester United in the Premier League after 19 attempts
MATCH ODDS: Palace 9/4 Draw 12/5 Man Utd 27/20
bet365 Pick: Crystal Palace To Win @9/4
ANDY SAYS: I am backing my former club to get something from this game…1-1
GRAEME SAYS: United have a lot of injuries, but I think they can win…1-2
Football Index – One to follow: Marcus Rashford – Still full of value on the Index
Liverpool 20:00 Watford
TEAM NEWS: Liverpool are waiting on Roberto Firmino, Naby Keita and Andrew Robertson. Joe Gomez, Dejan Lovren and Alex Oxlade-Chamberlain remain sidelined.
Kiko Femenia remains the only player sidelined for Watford.
KEY FACT: Liverpool are unbeaten in their last six league meetings with Watford
MATCH ODDS: Liverpool 2/7 Draw 5/1 Watford 11/1
bet365 Pick: Under 2.5 goals @11/8
ANDY SAYS: Liverpool will just be far too strong for Watford, no doubt for me…3-1
GRAEME SAYS: I do wonder if Watford could get something from Anfield, there will be goals…2-2
Football Index – One to follow: Sadio Mane – Could offer some real value if he hits form in the last few months of the season
Manchester City 20:00 West Ham United
TEAM NEWS: Man City are without Fernandinho, Aymeric Laporte, John Stones and Gabriel Jesus but Benjamin Mendy could be involved.
Jack Wilshere, Andriy Yarmolenko, Fabian Balbuena and Winston Reid are all sidelined, but Manuel Lanzini is involved after his lenghty injury lay-off.
KEY FACT: West Ham have only ever won once at The Etihad
MATCH ODDS: Man City 1/6 Draw 8/1 West Ham 18/1
bet365 Pick: Both Teams To Score @Evens
ANDY SAYS: Little doubt Man City win this for me…3-0
GRAEME SAYS: Home win coming for sure…2-0
Football Index – One to follow: Raheem Sterling – Still looks great value
