Manchester City look to move back to the top-of-the-table on Wednesday, as Tottenham begin life in their new home at White Hart Lane as continue their battle for a top-four place.
City have a game in hand over leaders Liverpool and this is it as they host third from bottom Cardiff City at the Etihad. A shock win for The Bluebirds would put them within touching distance of safety.
The big game on Wednesday is in North London as finally Spurs being life in their wonderful new stadium and they will be more than hopeful of beating Crystal Palace.
Chelsea are also in action as they also look to keep up in the race for top-four, with Brighton the visitors to Stamford Bridge.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Chelsea 19:45 Brighton & Hove Albion
TEAM NEWS: Brighton are still without Pascal Gross but Florin Andone could feature – although Brighton could rest players ahead of this weekend’s FA Cup semi-final.
Maurizio Sarri could hand a first leg start to Callum Hudson-Odoi, but Marcos Alonso has joined Ethan Ampadu and Davide Zappacosta on the sidelines.
KEY FACT: Chelsea have lost just once at home this season
MATCH ODDS: Chelsea 2/7 Draw 5/1 Brighton 12/1
bet365 Pick: Under 2.5 goals @11/10
ANDY SAYS: Don’t think Brighton will be 100% concentrated here so home win…2-0
GRAEME SAYS: Chelsea should win this with something to spare…3-0
Football Index – One to follow: Callum Hudson-Odoi – Set for his first league start, this boy is on the rise
Manchester City 19:45 Cardiff City
TEAM NEWS: Vincent Kompany and Benjamin Mendy are set to be available for City, but Sergio Aguero is sidelined along with Fabian Delph.
Cardiff’s Jazz Richards could make his first appearance of the season, but Sol Bamba and Callum Paterson remain sidelined.
KEY FACT: Man City are unbeaten in their last 35 Premier League home matches against promoted sides
MATCH ODDS: Man City 1/20 Draw 18/1 Cardiff 40/1
bet365 Pick: Man City win & under 4.5 goals @5/6
ANDY SAYS: Very easy win coming up, a matter of how many for City…5-0
GRAEME SAYS: This could be a huge score, easy home win…6-0
Football Index – One to follow: Phil Foden – Should get his chance in this game, a stunning talent
Tottenham Hotspur 19:45 Crystal Palace
The Tottenham Hotspur Stadium
TEAM NEWS: Harry Winks is available again for Tottenham, but Eric Dier, Serge Aurier and Eric Lamela remain sidelined.
Palace have a near fully fit squad to choose from with the only absentee being Mamadou Sakho.
KEY FACT: This is the first ever league game in Tottenham’s new stadium
MATCH ODDS: Spurs 9/20 Draw Draw 4/1 Palace 13/2
bet365 Pick: First goal Harry Kane @12/5
ANDY SAYS: Spurs open up the new stadium with victory…2-1
GRAEME SAYS: Tottenham need the win and I believe they get it…3-0
Football Index – One to follow: Harry Kane – He still has value left in him on the Index