Manchester City have the chance to move back to the top of the Premier League on Wednesday, but they will have to win at Old Trafford to do so.
Manchester United are still looking to claim a top-four spot, but to do so they will likely have to take something from their clash with City.
The night’s other game also involves the battle for top-four as Arsenal travel to Wolves – who are still pushing for a top-seven finish.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Wolverhampton Wanderers 19:45 Arsenal
Molineux
TEAM NEWS: Wolves again have the luxury of a fully-fit squad to choose from.
Arsenal hope that Granit Xhaka will be fine whilst Sokratis Papastathopoulos returns from suspension, but Aaron Ramsey and Denis Suarez are sidelined along with Hector Bellerin, Rob Holding and Danny Welbeck.
KEY FACT: Wolves are looking for their first PL victory over Arsenal at the 10th attempt
MATCH ODDS: Wolves 9/5 Draw 5/2 Arsenal 8/5
bet365 Pick: Over 2.5 goals @10/11
ANDY SAYS: I think that Wolves bounce back to some form and claim the big win…2-0
GRAEME SAYS: Tough game, but should be a good one and I see Arsenal grabbing the win…1-2
Football Index – One to follow: Ruben Neves – The Wolves midfielder is an outstanding talent
Manchester United 20:00 Manchester City
Old Trafford
TEAM NEWS: Manchester City have a near fully fit squad to choose from, although Kevin De Bruyne is sidelined.
Phil Jones is sidelined along with Antonio Valencia, but Ander Herrera should return from injury along with Luke Shaw – whose suspension has finished.
KEY FACT: Manchester City have won five of their last seven Premier League fixtures at Old Trafford
MATCH ODDS: Man Utd 13/2 Draw 4/1 Man City 4/9
bet365 Pick: Under 2.5 goals @11/8
ANDY SAYS: City are going to be far too strong for United, away win…1-3
GRAEME SAYS: This will be close but I don’t see how United don’t win…1-2
Football Index – One to follow: Bernardo Silva – No better player on form than this guy right now, plenty of value in him
