Manchester United, Tottenham Hotspur and Leicester City are all in action on Wednesday evening.
Leicester are at home to West Ham, Tottenham host Norwich whilst United welcome Burnley to Old Trafford.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Leicester City 19:30 West Ham United
King Power Stadium
TEAM NEWS: Daniel Amartey remains sidelined for Leicester, but he could be the only absentee with Wilfried Ndidi and Matty James in contention. | Michail Antonio could be available for West Ham, who are without Jack Wilshere, Andriy Yarmolenko, Ryan Fredericks, Felipe Anderson and Lukasz Fabianski.
KEY FACT: Brendan Rodgers has not lost three successive matches since November 2014
MATCH ODDS: Leicester 1/2 Draw 7/2 West Ham 5/1
bet365 Pick: Jamie Vardy to score first @9/4
ANDY SAYS: Have not been convinced by Leicester in recent weeks and I think that West Ham get something here…1-1
GRAEME SAYS: I think that Leicester will bounce back to some form and claim the win…2-1
Football Index – One to follow: James Maddison – Needs to start getting back to top form
Tottenham Hotspsur 19:30 Norwich City
Tottenham Hotspur Stadium
TEAM NEWS: Tanguy Ndombele and Danny Roses could feature for Spurs, but Harry Kane, Ben Davies and Moussa Sissoko and Hugo Lloris remain sidelined. | Emiliano Buendia, Mario Vrancic, Ralf Fahrmann and Timm Klose are unavailable, while Ben Godfrey is suspended.
KEY FACT: Spurs have been victorious in their last nine Premier League home games they have played on a Wednesday
MATCH ODDS: Spurs 4/11 Draw 17/4 Norwich 13/2
bet365 Pick: Norwich Half Time/Spurs Full Time @18/1
ANDY SAYS: Spurs will be too good for Norwich in this one…2-0
GRAEME SAYS: Spurs will be far too strong for Spurs in this one…3-0
Football Index – One to follow: Dele Alli – Really starting to hit form again
Manchester United 20:15 Burnley
TEAM NEWS: Luke Shaw, Victor Lindelof and Timothy Fosu-Mensah are set to be available for United but Scott McTominay, Paul Pogba, Marcos Rojo, Axel Tuanzebe and Marcus Rashford are ruled out. | Burnley could have Johann Gudmundsson back meaning the only player missing for them would be Ashley Barnes.
KEY FACT: This will be Man Utd’s first match at Old Trafford in the Premier League under Ole Gunnar Solskjaer that Marcus Rashford
MATCH ODDS: Man Utd 2/5 Draw 18/5 Burnley 7/1
bet365 Pick: Under 2.5 goals @10/11
ANDY SAYS: I think that Burnley have enough here to claim a point…1-1
GRAEME SAYS: This won’t be easy, but I think United should have enough to land the win…2-1
Football Index – One to follow: Anthony Martial – The time is now on the Frenchman to step up