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League leaders Manchester City look to maintain their unbeaten start to the season as they host Southampton.
City’s brilliant form was tested at Huddersfield at the weekend, but they are looking for their 12th consecutive win against the Saints.
Champions Chelsea, currently in third, are looking to continue their excellent run of form as they welcome second-bottom Swansea to Stamford Bridge.
Arsenal are on the hunt for their third win in succession as they host Huddersfield at The Emirates.
Liverpool are looking to keep up the pressure on the top-four as they travel to Stoke – who are looking to stay out of the bottom three.
Managerless Everton face West Ham in a crunch game at Goodison Park – victory for West Ham would take them above the Toffees, who could drop into the relegation places.
At the Vitality Stadium – Bournemouth host high-flying Burnley, looking for a victory that would take them into the top-half of the table.
See below for a preview on each games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Arsenal 19:45 Huddersfield Town
Emirates Stadium
TEAM NEWS: Mesut Ozil and Alex Iwobi are both doubts for Arsenal and will be checked on before kick-off. Raji van La Parra is suspended, whilst Philip Billing, Michael Hefele and Jon Gorenc Stankovic are injured.
KEY FACT: Arsenal have won 11 Premier League home matches in a row
MATCH ODDS: Arsenal 1/5 Draw 13/2 Huddersfield 16/1
bet365 Pick: Arsenal to win to nil @4/5
ANDY SAYS: Has to be a home win, Arsenal are playing pretty well…2-0
GRAEME SAYS: Have to go with Wenger’s boys here to get the three points…3-1
SILKY SAYS: Comfortable home win here, don’t think that they will slip-up…3-0
FOOTBALLIndex – One to follow: Alexandre Lacazette at less than £3
Bournemouth 19:45 Burnley
Vitality Stadium
TEAM NEWS: Simon Francis returns from suspension for Bournemouth but Junior Stanislas is out whilst Jermain Defoe is a major doubt. Matt Lowton will have a fitness test before the match whilst Jon Walters won’t be risked despite returning to training.
KEY FACT: Bournemouth are on their best run of consecutive PL clean sheets (three)
MATCH ODDS: Bournemouth Evens Draw 12/5 Burnley 10/3
bet365 Pick: Bournemouth @Evens
ANDY SAYS: Tough call so I think I will have to go for a draw…1-1
GRAEME SAYS: I think Bournemouth will do enough here, they have been improving…2-0
SILKY SAYS: Close game, before playing decent at the moment – a draw…1-1
FOOTBALLIndex – One to follow: Josh King is in the INDEX top-100 at £1.51
Chelsea 19:45 Swansea City
Stamford Bridge
TEAM NEWS: Victor Moses is fit again for the first time since October but David Luiz, Michy Batshuayi and Kenedy are sidelined. Swansea’s Federico Fernandez misses out due to a family death, whilst Kyle Bartley remains sidelined and Tammy Abraham can’t face his parent club.
KEY FACT: Swansea are aiming to become the first Welsh side to win at Chelsea in the PL
MATCH ODDS: Chelsea 2/11 Draw 7/1 Swansea 16/1
bet365 Pick: Chelsea to win and under 3.5 goals @20/21
ANDY SAYS: Chelsea should be comfortable, don’t see Swansea troubling them…3-0
GRAEME SAYS: Swansea may not be as easy as some think, but Chelsea will win…3-1
SILKY SAYS: Think Chelsea will dish out a bit of a hammering here…5-0
FOOTBALLIndex – One to follow: Andreas Christensen at £1.58 – now one of the best rated defenders on the INDEX
Everton 20:00 West Ham United
Goodison Park
Live On BT Sport
TEAM NEWS: Mason Holgate could return for Everton, but Leighton Baines and Michael Keane are major doubts. Javier Hernandez will not be involved for West Ham, whilst Michail Antonio and James Collins are unlikely to be risked.
KEY FACT: Everton have lost only one of their last 18 Premier League matches against West Ham
MATCH ODDS: Everton 7/5 Draw 23/10 West Ham 23/10
bet365 Pick: Draw @23/11
ANDY SAYS: I don’t see Everton winning this but they should have enough to claim a point…1-1
GRAEME SAYS: Have to go for a draw, two very poor sides indeed…2-2
SILKY SAYS: A tough one, I am going for West Ham but could easily go the other way…1-2
FOOTBALLIndex – One to follow: Marko Arnautovic at just under a £1, could be good value
Manchester City 20:00 Southampton
Etihad Stadium
TEAM NEWS: Benjamin Mendy and John Stones both remain sidelined for City. Oriol Romeu is back from suspension for Southampton but Matt Targett is still out.
KEY FACT: Man City have the best-ever points total by a team after 13 matches of a Premier League season
MATCH ODDS: Man City 1/5 Draw 7/1 Southampton 14/1
bet365 Pick: Both Teams To Score @21/20
ANDY SAYS: You just can’t see past Man City, don’t think it will be a hammering though…3-1
GRAEME SAYS: Comfortable win for Man City, they will get the three points…3-0
SILKY SAYS: Three points for City all the way, depends how quickly they take the lead…4-1
FOOTBALLIndex – One to follow: Kevin De Bruyne under £4 and not in top-ten, how is that possible?
Stoke City 20:00 Liverpool
bet365 Stadium
TEAM NEWS: Emre Can and Dejan Lovren are both set to return for Liverpool. Ramadan Sobhi is a doubt, whilst Geoff Cameron and Jack Butland are sidelined.
KEY FACT: Liverpool have won seven of their last eight Premier League matches against Stoke
MATCH ODDS: Stoke 21/4 Draw 18/5 Liverpool 8/15
bet365 Pick: Both Teams To Score @4/6
ANDY SAYS: I can see Liverpool taking this without too many issues…0-3
GRAEME SAYS: Depends which Liverpool turn up, but will give them the benefit, just…0-1
SILKY SAYS: Easy Liverpool win for me, don’t see them having too much trouble…0-3
FOOTBALLIndex – One to follow: Mo Salah under £4 but still climbing the INDEX.