Leaders Manchester City are in action in the only goal of the game on Wednesday.
City travel to St James’ Park to take on Rafa Benitez’s side looking to defend their unbeaten start to the season and their current winning streak of 17 games.
Newcastle are currently in 15th, two points above the drop-zone.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Newcastle United 19:45 Manchester City
St James’ Park
Live On Sky Sports
TEAM NEWS: Newcastle are hoping to have Mikel Merino and Isaac Hayden available despite suffering knocks. John Stones and Vincent Kompany should be fit for City but Phil Foden has joined Benjamin Mendy on the sidelines.
KEY FACT: Newcastle have won only three points from their last 57 available in the Premier League against Man City
MATCH ODDS: Newcastle 12/1 Draw 23/4 Man City 1/4
bet365 Pick: Man City to win and Both Teams to Score @8/5
ANDY SAYS: Have to go with City, don’t see Newcastle testing them too much…0-3
GRAEME SAYS: Has to be an away win, but might not be as easy as some think…0-2
SILKY SAYS: Comfortable City victory – easy three points for me…0-4
FOOTBALLIndex – One to follow: Under £4 – why isn’t Kevin De Bruyne higher?