There is an action packed Wednesday night programme in the Premier League with a near full set of fixtures with both Manchester City and Manchester United in action.

12 points currently separates the two neighbours, so by the end of the evening the lead could be back to 15-points or cut to 9.

City host bottom-of-the-table West Brom at the Etihad, whilst United are at Wembley for a mouthwatering looking clash with fifth placed Tottenham – who are now five points adrift of the top-four.

Should United lose, then Chelsea in third could go above them with victory over Bournemouth at Stamford Bridge.

There is a huge South Coast derby with second from bottom Southampton hosting Brighton in 16th – victory for The Saints would lift them above the Seagulls.

Third bottom Stoke could move back out of the relegation places with victory over Watford at the bet365 Stadium.

Newcastle in 15th could drop into the bottom three with defeat so they will be eager for maximum points at home to Burnley.

Finally, Everton are looking to bounce back to form as they host seventh-placed Leicester at Goodison Park.

See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.

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Chelsea 19:45 AFC Bournemouth
Stamford Bridge

TEAM NEWS: Thibaut Courtois and Cesc Fabregas are available for Chelsea but Alvaro Morata, David Luiz  and Willian are ruled out. Jermain Defoe remains sidelined for Bournemouth but Joshua King and Juniior Stanislas are available
KEY FACT: Chelsea have kept four consecutive home clean sheets in the Premier League
MATCH ODDS: Chelsea 3/10 Draw 5/1 Bournemouth 10/1
bet365 Pick: Chelsea to win & Both Teams to Score @8/5
ANDY SAYS: Could be closer than some think but still Chelsea win…2-1
GRAEME SAYS: You have to think Chelsea are getting the three points from this one…2-0
SILKY SAYS: Easy home win, don’t see it any other way…3-0
FOOTBALLIndex – One to follow:  Thibaut Courtois remains a fine pick on the Index

Everton 19:45 Leicester City
Goodison Park

TEAM NEWS: Everton welcome back Seamus Coleman after 10-months sidelined, but James McCarthy faces a similar time out. The only absentee for Leicester is captain Wes Morgan.
KEY FACT: Everton have won two of their last three Premier League meetings with Leicester
MATCH ODDS: Everton 2/1 Draw 11/5 Leicester 13/8
bet365 Pick: Draw @11/5
ANDY SAYS: Tough call would have to say a draw…1-1
GRAEME SAYS: Not many goals, but maybe Everton edging it…1-0
SILKY SAYS: Not much separating these two, would say draw…1-1
FOOTBALLIndex – One to follow:  Now Seamus Coleman is back, he is one to get on again

Newcastle 19:45 Burnley
St. James’ Park

TEAM NEWS: New signing Kenedy is in-line to make his debut for Newcastle. Steven Defour and James Tarkowski are major doubts for Burnley, whilst Dean Marney, Stephen Ward, Chris Wood and Tom Heaton are out.
KEY FACT: Newcastle United have won only one of their last eight league matches against Burnley
MATCH ODDS: Newcastle 6/5 Draw 11/5 Burnley 29/10
bet365 Pick: Newcastle to win to nil @21/10
ANDY SAYS: Tough call, but I think home win just about…2-1
GRAEME SAYS: I see Burnley taking the three points here…0-2
SILKY SAYS: I think this could be a draw…1-1
FOOTBALLIndex – One to follow: Kenedy could be one to watch out for on the Index now

Southampton 19:45 Brighton
St. Mary’s Stadium

TEAM NEWS: Charlie Austin remains sidelined, whilst a late decision will be made on Ryan Bertrand and new signing Guido Carrillo. Steve Sidwell and Jiri Skalak are out for Brighton, whilst record signing Jurgen Locadia may not be risked.
KEY FACT: Southampton have lost only one of their last 27 Premier League home matches against promoted teams 
MATCH ODDS: Southampton 3/4 Draw 5/2 Brighton 5/1
bet365 Pick: Southampton to win @3/4
ANDY SAYS: Close call but have to think that Southampton take this…1-0
GRAEME SAYS: Can see these two rivals cancelling each other out…0-0
SILKY SAYS: Won’t be much in this but have to give edge to Southampton being at home…0-0
FOOTBALLIndex – One to follow: Guido Carrillo could be one to keep an eye on in the Index following his move

Man City 20:00 West Brom
Etihad Stadium

TEAM NEWS: Man City could hand a debut to new record signing Aymeric Laporte, but Leroy Sane has joined Gabriel Jesus, Benjamin Mendy and Fabian Deplh on the sidelines. New signings Daniel Sturridge and Ali Gabr both could feature for West Brom, but Jonny Evans and Hal Robson-Kanu are doubts.
KEY FACT: Man City have won 15 of their last 16 Premier League encounters with West Brom
MATCH ODDS: Man City 1/7 Draw 17/2 West Brom 20/1
bet365 Pick: Both Teams to Score @5/4
ANDY SAYS: Convincing Man City win for me…4-1
GRAEME SAYS: Not sure City will find this easy but they will win…2-0
SILKY SAYS: Home win, little doubt really…3-0
FOOTBALLIndex – One to follow:  Aymeric Laporte could be one to watch on the Index

Stoke 20:00 Watford
bet365 Stadium

TEAM NEWS: Konstantinos Stafylidis is in contention to make his debut for Stoke, but Glen Johnson and Jese Rodriguez remain out. Watford could give a debut to new signing Gerard Deulofeu, whilst his former Everton team-mate Tom Cleverley is fit but Heurelho Gomes is likely to miss out.
KEY FACT: Stoke can win back-to-back PL matches for the first time since January 2017
MATCH ODDS: Stoke 5/4 Draw 5/2 Watford 12/5
bet365 Pick: Both Teams to Score @4/6
ANDY SAYS: Close game, but Stoke have come good under Paul Lambert so home win…1-0
GRAEME SAYS: I can only see a home win at the moment from this one…2-0
SILKY SAYS: Not sure I can separate these two, goalless draw…0-0
FOOTBALLIndex – One to follow: Gerard Deulofeu should be a good investment on the Index

Spurs 20:00 Man Utd
Wembley Stadium

TEAM NEWS: Christian Eriksen, Erik Lamela, Hugo Lloris and Danny Rose could all return for Spurs but Toby Alderweireld, Serge Aurier and Harry Winks are sidelined. Alexis Sanchez is set to make his league debut for United, who are still without Zlatan Ibrahimovic and Eric Bailly.
KEY FACT: Spurs have won two of their seven Premier League matches against Man Utd under Mauricio Pochettino
MATCH ODDS: Spurs 13/10 Draw 12/5 Man Utd 12/5
bet365 Pick: Under 2.5 goals @9/10
ANDY SAYS: I am going for my former side here, but should be a close one…2-1
GRAEME SAYS: Fascinating encounter for sure, have to go draw…2-2
SILKY SAYS: Good game, and I will say United will have enough to claim the win…1-2
FOOTBALLIndex – One to follow:  Alexis Sanchez is one of the top players in the Index, but still worth a look