The Premier League returns to action on this weekend with some move water clashes, including leaders Manchester United looking to maintain their perfect start to the campaign.

Jose Mourinho’s side are the only team left with a 100 per cent record and they will be hopeful of a fourth straight win although they face the always tricky prospect of a trip to Stoke City – which is the final match of the day.

The day begins in Manchester with the biggest game of the weekend as Man City host Liverpool at The Etihad. Both teams have enjoyed unbeaten starts to the season and victory for either would send them top, albeit possibly temporarily with United playing later.

West Brom are another side who could find themselves on top at some point on Saturday and they travel to newly promoted Brighton & Hove Albion – who are looking for their first win since they returned to the top-flight.

Reigning champions Chelsea travel to the King Power off the back of two impressive wins as they take on Leicester.

Tottenham, who are yet to win at their temporary home of Wembley, are looking to continue their good away form – but face a tough looking task at Everton – who have won just once so far this season.

Watford and Southampton, who have both enjoyed undefeated starts to the new season and both sit on a healthy five points after three games, clash at St Mary’s.

Finally, Arsenal are looking to put a disappointing transfer widow behind them and end a two-game losing streak as they host Bournemouth at The Emirates.

See below for a run-down on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, leading agent Barry Silkman and our own Football Insider Graeme Bailey together with everything you need to know from the bookies – with Ladbrokes’s Alex Apati.

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Man City 12:30 Liverpool
Etihad Stadium
Live On Sky Sports

TEAM NEWS: Vincent Kompany picked up a knee injury in midweek so is a doubt, whilst Ilkay Gundogan could be involved. Raheem Sterling is suspended by Kyle Walker returns from his ban. Nathaniel Clyne and Adam Lallana remained sidelined for Liverpool and Philippe Coutinho will not be involved.
KEY FACT: Manchester City have lost only one of their last eight home Premier League meetings against Liverpool
MATCH ODDS: Man City 5/6 Draw 14/5 Liverpool 29/10
ANDY SAYS: I can see this being a bit of a classic with Liverpool coming out on top…2-3
GRAEME SAYS: I think this will be close, even a draw – two good teams…1-1
SILKY SAYS: I have to go with the home side in this one, but close…2-1
LADBROKES PICK: Man City/Man City HT/FT @ 2/1
FOOTBALLIndex – One to follow: Gabriel Jesus at just over £4 is a wonderful pick-up for any portfolio

Arsenal 15:00 Bournemouth
Emirates Stadium

TEAM NEWS: Jack Wilshere could be back in the squad for Arsenal but Santi Cazorla remains sidelined. Alexis Sanchez could start. Simon Francis, Junior Stanislas and Nathan Ake are all doubts whilst Callum Wilson remains sidelined. 
KEY FACT: Arsenal have not lost three successive Premier League matches since January 2012
MATCH ODDS: Arsenal 4/11 Draw 4/1 Bournemouth 7/1
ANDY SAYS: I can see Arsenal’s misery continuing here, Bournemouth shock win…0-1
GRAEME SAYS: I just don’t see Bournemouth getting anything here, Arsenal win…2-0
SILKY SAYS: Comfortable Arsenal win here, I can see them winning this one comfortably…4-1
LADBROKES PICK: Arsenal to win & BTTS @ 6/4
FOOTBALLIndex – One to follow: Has to be Alexis Sanchez, at number two on the INDEX – still a solid buy

Brighton 15:00 West Brom
Amex Stadium

TEAM NEWS: Kieran Gibbs and Grzegorz Krychowiak could feature for West Brom and make their debuts, but Gareth McAuley is a major doubt whilst Hal Robson-Kanu is suspended. Tomer Hemed, Beram Kayal and Izzy Brown are major doubts for Brighton.
KEY FACT: This is the first league meeting between these teams since April 1993
MATCH ODDS: Brighton 31/20 Draw 19/10 West Brom 2/1
ANDY SAYS: I can see Brighton’s first win coming here and they will just edge it…1-0
GRAEME SAYS: West Brom have started well and they will have too much for Brighton…0-1
SILKY SAYS: Has to be a West Brom win, not sure where Brighton’s first win is coming from…0-2
LADBROKES PICK: West Brom to win @ 2/1
FOOTBALLIndex – One to follow: No Brighton or West Brom player but Anthony Knockaert is 4th on the squad list

Everton 15:00 Spurs
Goodison Park

TEAM NEWS: Seamus Coleman, Ramiro Funes Mori, Yannick Bolasie and Ross Barkley are all unlikely to play again this year. Davy Klaassen and James McCarthy are also major doubts but Morgan Schneiderlin is back from suspension. Erik Lamela and Danny Rose remain sidelined for Spurs, whilst new signing Fernando Llorente is not ready to play due to his broken arm but Serge Aurier could make his debut.
KEY FACT: Spurs have won their last three PL away matches
MATCH ODDS: Everton 13/5 Draw 23/10 Spurs 21/10
ANDY SAYS: Tottenham are very good away from home so can see them winning this…1-2
GRAEME SAYS: Another tough call this one – have to go draw but can see goals…2-2
SILKY SAYS: Yeah a close match this one, but a good one…2-2
LADBROKES PICK: Everton or Draw @ 7/10
FOOTBALLIndex – One to follow: Idrissa Gueye is available at just over over 50p, surely a bargain?

Leicester 15:00 Chelsea
King Power Stadium

TEAM NEWS: Eden Hazard is set to be included for the first time this season, whilst Diego Costa remains AWOL. Danny Drinkwater is available to make his debut against his former club having overcome a thigh problem. Robert Huth and summer signing Vicente Iborra could feature for the first time this season for Leicester. Kelechi Iheanacho and deadline day recruit Aleksandar Dragovic are included. Adrien Silva can’t play as his registration was rejected by FIFA.
KEY FACT: Chelsea have not won away from home in the month of September in any of their previous four PL seasons
MATCH ODDS: Leicester 7/2 Draw 13/5 Chelsea 3/4
ANDY SAYS: Tough one but I think Leicester will get something from this so draw…1-1
GRAEME SAYS: Chelsea have looked good to me and with Hazard back, away win…1-3
SILKY SAYS: I think Leicester might just hold Chelsea in this one…1-1
LADBROKES PICK: Danny Drinkwater to score at any time @ 5/1
FOOTBALLIndex – One to follow: Jamie Vardy available at less than a £1 – come on, is there a better buy in the Index?

Southampton 15:00 Watford
St. Mary’s Stadium

TEAM NEWS:  Southampton want-away captain Virgil Van Dijk is unlikely to be involved but fellow Dutchman Wesley Hoedt could make his debut. Craig Cathcart will not play again this year for Watford but new signing  Molla Wague could make his debut.
KEY FACT: Watford’s Marco Silva will be aiming for back-to-back away league victories for the first time in his managerial career
MATCH ODDS: Southampton 8/13 Draw 14/5 Watford 9/2
ANDY SAYS: I think Southampton will have too much for Watford in this one…2-0
GRAEME SAYS: Another close game, but I think Southampton but it will be close…2-1
SILKY SAYS: A draw for me here, both have had good starts to the season…1-1
LADBROKES PICK: Both teams to score @ 19/20
FOOTBALLIndex – One to follow: Virgil van Dijk should be ready to play again soon, great buy at less than £1.50

Stoke 17:30 Man Utd
bet365 Stadium
Live On BT Sport

TEAM NEWS: Marcos Rojo and recently re-signed Zlatan Ibrahimovic remain sidelined but Luke Shaw and Ashley Young could be included in the squad after returning to full training. Eric Choupo-Moting and former United ace Darren Fletcher should both be fit despite missing the recent World Cup qualifiers due to injury, but Ryan Shawcross is out.
KEY FACT: Mark Hughes is unbeaten in his last three PL meetings with Jose Mourinho 
MATCH ODDS: Stoke 6/1 Draw 3/1 Man Utd 1/2
ANDY SAYS: Comfortable away win for United once they have got through the Stoke defence…1-3
GRAEME SAYS: I think Jose might just get United through this, but only just…1-2
SILKY SAYS: Easy win for United here, comfortable…0-3
LADBROKES PICK: Lukaku to score at any time @ 10/11
FOOTBALLIndex – One to follow: £2.63 – in great form, get on Henrikh Mkhitaryan